PAH risk factors identified for systemic sclerosis patients

Author: Lucy Piper
Date Published: May-2014
Source: Medwire News

Researchers have identified clinical features that could help predict which patients with systemic sclerosis (SSc) are likely to go on to develop pulmonary arterial hypertension (PAH) and therefore benefit most from early treatment. They found that SSc-related PAH was more likely to develop in patients who had a low diffusion capacity for carbon monoxide (DLco; <55% predicted) and therefore a high ratio of forced vital capacity (FVC) to DLco (>1.6), an echocardiogram systolic pulmonary arterial pressure (sPAP) above 40 mmHg and exercise-induced hypoxia.