Avenues for protecting against vasculopathy in systemic sclerosis

Author: Sharon Worcester
Date Published: May-2014
Source: Rheumatology News

One Rho-kinase inhibitor – fasudil – is approved for use in Japan, and an inhaled formulation is currently being studied for pulmonary hypertension. Stem cells Studies in Japan of human mesenchymal stem cells suggest that bone-marrow-derived stem cells injected directly into the skin of patients with digital ulcers leads to improvement in the ulcers over time. "There was no control group, so it’s not clear that the treatment was the reason for the benefit, but it is an interesting concept. Instead of stimulating the bone marrow to get stem cells, why not just inject them into the skin," he said.