Abnormally Differentiating Keratinocytes in the Epidermis of Systemic Sclerosis Patients Show Enhanced Secretion of CCN2 and S100A9

Author: Nikitorowicz-Buniak J, Shiwen X, Denton CP, Abraham D, Stratton R.
Date Published: June-2014
Source: Journal of Investigative Dermatology

Skin involvement with dermal fibrosis is a hallmark of systemic sclerosis and keratinocytes may be critical regulators of fibroblast function through secretion of chemo-attracting agents, as well as growth factors and cytokines influencing phenotype and proliferation rate of fibroblasts, and epithelial-fibroblast interactions have an important role in fibrosis in general. We have characterised SSc epidermis and asked whether SSc injured epidermal cells are releasing factors capable of promoting fibrosis.