Effect of menopause on the modified Rodnan skin score in systemic sclerosis

Author: É. Vinet, S. Bernatsky, M. Hudson, C. Pineau and M. Baron
Date Published: June-2014
Source: Arthritis Research & Therapy

Introduction We aimed to evaluate the effect of menopause on skin thickening, as measured by the modified Rodnan skin score (mRSS), in women with systemic sclerosis (SSc). Methods We identified women with either limited or diffuse SSc, aged >= 18 years, enrolled within the Canadian Scleroderma Research Group (CSRG) cohort, between 2004 and 2011. As part of the CSRG cohort, subjects undergo annual assessments with standardized questionnaires and physical examinations. We performed multivariate regression analyses using generalized estimating equation (GEE) to determine the effect of menopause on the mRSS, adjusting for relevant covariates including notably age, follow-up time, and disease duration.