Fibrosis—a lethal component of systemic sclerosis

Author: Yuen Yee Ho, David Lagares, Andrew M. Tager & Mohit Kapoor
Date Published: June-2014
Source: Nature Reviews Rheumatology

Fibrosis is a pathological process characterized by excessive accumulation of connective tissue components in an organ or tissue. Fibrosis is produced by deregulated wound healing in response to chronic tissue injury or chronic inflammation, the hallmarks of rheumatic diseases. Progressive fibrosis, which distorts tissue architecture and results in progressive loss of organ function, is now recognized to be one of the major causes of morbidity and mortality in individuals with one of the most lethal rheumatic disease, systemic sclerosis (SSc).