Autoimmunity: Regulatory B cells—IL-35 and IL-21 regulate the regulators

Author: Thomas F. Tedder & Warren J. Leonard
Date Published: June-2014
Source: Nature Reviews Rheumatology

IL-21 regulates the activity and number of IL-10-producing regulatory B cells (B10 cells) that modulate immune responses and limit diverse autoimmune diseases. A new study demonstrates that IL-35 has a similar function. Identifying regulatory circuits that control B10-cell function in vivo might open the door to future treatments for autoimmune diseases.