Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis

Author: A. Catrina, A. Ytterberg, G. Reynisdottir, V. Malmström & L. Klareskog
Date Published: July-2014
Source: Nature Reviews Rheumatology

Rheumatoid arthritis (RA) is a prototype for a criterion-defined inflammatory disease, for which the aetiology and initial molecular pathogenesis has been elusive for a long time. We describe in this Review how studies on the interplay between specific immunity, alongside genetic and environmental predisposing factors, provide new tools to understand the molecular basis of distinct subsets of the disease. A particular emphasis is on the possibility that pathogenic immune reactions might be initiated at other sites than the joints, and that the lungs could harbour such sites.