For Patients

If you have scleroderma, you are not alone. The National Institutes of Health, America’s leading supporter of medical research, estimates that approximately 300,000 people suffer from scleroderma-related disorders.

The first time many people hear about scleroderma is when they, a family member or friend are diagnosed with the disease. Scleroderma is a complex and surprisingly widespread illness, affecting as many people as more commonly recognized diseases such as multiple sclerosis and muscular dystrophy.

In addition to funding the most promising research aimed at improved therapies and a cure, the Scleroderma Research Foundation provides information that may help scleroderma patients better understand their disorder and more effectively manage its symptoms.

To learn more about the various forms and subtypes of scleroderma, please click here. This section of the Scleroderma Research Foundation’s Web site provides information for patients to educate themselves, as well as their caretakers and loved ones, about this serious disease.

Please remember, information provided on this Website and others is intended as a guide. Specific medical advice can only be provided by your health care professional.


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Research News

Antagonistic Effect of the Matricellular Signaling Protein CCN3 on TGF-β- and Wnt-Mediated Fibrillinogenesis in Systemic Sclerosis and Marfan Syndrome

Author:Raphael Lemaire, Giuseppina Farina, Julie Bayle, Michael Dimarzio, Sarah A Pendergrass, Ausra Milano, Michael L Whitfield and Robert Lafyatis
Date Published: February-2010
Source: 

Abnormal fibrillinogenesis is associated with connective tissue disorders (CTDs), including Marfan syndrome (MFS), systemic sclerosis (SSc) and Tight-skin (Tsk) mice. We have previously shown that TGF-β and Wnt stimulate fibrillin-1 assembly and that fibrillin-1 and the developmental regulator CCN3 are both highly increased in Tsk skin.

Medical Mystery Pieced Together

Author:
Date Published: January-2010
Source: The Boston Channel.com

A troubling medical puzzle in South Boston has finally been pieced together. A relatively small community has an alarming number of cases of a debilitating disease.

IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus.

Author: Richez C, Yasuda K, Bonegio RG, Watkins AA, Aprahamian T, Busto P, Richards RJ, Liu CL, Cheung R, Utz PJ, Marshak-Rothstein A, Rifkin IR.
Date Published: January-2010
Source: Pubmed

Polymorphisms in the transcription factor IFN regulatory factor 5 (IRF5) are strongly associated in human genetic studies with an increased risk of developing the autoimmune disease systemic lupus erythematosus.

Th1 transcription factor T-bet regulates the expression of Tim-3.

Author: Anderson AC, Lord GM, Dardalhon V, Lee DH, Sabatos CA, Glimcher LH, Kuchroo VK.
Date Published: January-2010
Source: Pubmed

Tim-3 (T cell immunoglobulin, mucin domain)-3 is a membrane protein expressed at late stages of IFN-gamma secreting CD4(+) T helper type 1 (Th1) cell differentiation and constitutively on dendritic cells (DC).

Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts.

Author: Shi-Wen X, Eastwood M, Stratton RJ, Denton CP, Leask A, Abraham DJ.
Date Published: January-2010
Source: Pubmed

Objective. The transcription factor peroxisome proliferator-activated receptor (PPAR)-gamma plays an important role in controlling cell differentiation.

News for Patients

Alternative Therapies for Raynaud’s

Author: Dr. Fredrick Wigley
Date Published: June-2010
Source: NY Times

Can biofeedback, fish oils, dietary supplements or other remedies ease the feelings of coldness, numbness and tingling in the fingers and toes of people with Raynaud’s disease?

Does Exercise Make Raynaud’s Worse?

Author: Dr. Fredrick Wigley
Date Published: May-2010
Source: NY Times

Can typing on a keyboard make coldness in the fingers feel worse? How about biking or vigorous exercise?

Ask the Expert: Raynaud’s Phenomenon

Author: Dr. Fredrick Wigley
Date Published: April-2010
Source: NY Times

“While it’s normal to feel cold when you step outside on a winter’s day without a jacket, the feeling of cold comes way too easily for sufferers of Raynaud’s,”

How Serious Is Raynaud’s Phenomenon?

Author: Dr. Fredrick Wigley
Date Published: May-2010
Source: NY Times

A troubling medical puzzle in South Boston has finally been pieced together. A relatively small community has an alarming number of cases of a debilitating disease.

Medical Mystery Pieced Together

Author:
Date Published: January-2010
Source: The Boston Channel.com

A troubling medical puzzle in South Boston has finally been pieced together. A relatively small community has an alarming number of cases of a debilitating disease.

Ways to Give

There are many ways that you can support the work of the Scleroderma Research Foundation. We are grateful for your commitment to helping the SRF fund research that will result in improved therapies and, ultimately, a cure.

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