Reversing the effects of pulmonary fibrosis with a microRNA mimic

Author: Jim Shelton
Date Published: September-2014
Source: YaleNews

Yale University researchers are studying a potential new treatment that reverses the effects of pulmonary fibrosis, a respiratory disease in which scars develop in the lungs and severely hamper breathing. The treatment uses a microRNA mimic, miR-29, which is delivered to lung tissue intravenously. In mouse models, miR-29 not only blocked pulmonary fibrosis, it reversed fibrosis after several days. The findings were published Sept. 19 in the journal EMBO Molecular Medicine.