Antibodies Predict Scleroderma Renal Crisis - Antibody test aids assessing risk for this potentially lethal complication.

Author: Nancy Walsh
Date Published: December-2014
Source: MedPage Today

The presence of a specific group of autoantibodies in patients with scleroderma was associated with a high risk of renal crisis, Japanese researchers reported. The scleroderma renal crisis occurred in 24% of patients who had anti-RNA polymerase III (RNAP III) antibodies but in only 1% of those without these autoantibodies, for an odds ratio of 21.6 (95% CI 7.8-60.3, P<0.00001), according to Manabu Fujimoto, MD, of the University of Tsukuba in Ibaraki, and colleagues.