Adiponectin May Prevent Skin Fibrosis in Systemic Sclerosis

Author: Alissa Woods, PhD
Date Published: December-2014
Source: Pulmonary Hypertension News

An international collaboration of researchers from the United States and China reported that adiponectin (APN), a protein that regulates glucose levels and fatty acid breakdown in the body, may be a naturally-occurring anti-fibrotic agent for systemic sclerosis (SSc). They presented their study at the 2014 American College of Rheumatology Meeting in November. Systemic sclerosis is an autoimmune and connective tissue disease. It is an uncommon, chronic disorder in which skin degeneration and scarring occurs, causing accumulation of collagen (fibrosis). Damage to the joints, internal organs and blood vessel abnormalities — particularly damage to small arteries — may also be present in SSc. Although anti-fibrotic agents have been studied for the treatment of skin fibrosis in SSc, so far no agent has been shown to be consistently beneficial.