Dangerous Clot Risks Higher in SSc – Especially in First Year after Diagnosis

Author: Rita Baron-Faust MPH
Date Published: July-2015
Source: Rheumatology Network

Patients diagnosed with systemic sclerosis (SSc) may have a three times greater risk of venous thromboembolism (VTE) – including potentially deadly clots in the lungs – and an increased risk in the first year after a diagnosis, according to a large population database study from Canada. The study of 1,245 SSc patients (83% female, mean age 56 years old),and 12,670 matched controls in British Columbia (BC), attributes the increased risk to vascular damage from SSc-related fibrosis that causes endothelial dysfunction and hypercoagulability due to inflammation.