Pathogenesis of the Raynaud phenomenon

Author: Fredrick M Wigley, MD
Date Published: May-2010
Source: UpToDate OnLine

One of the normal physiologic responses to cold temperature is the lowering of blood flow to the skin, thereby reducing the loss of body heat and preserving normal core temperature. Blood flow to the skin is regulated by a complex interactive system involving neural signals, circulating hormones, and mediators released from both circulating cells and blood vessels.


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