MD News and Information

Leading Researcher: Fibrosis Improved in Systemic Sclerosis and IPF Models With Monoclonal Antibody

Author: Margarida Azevedor
Date Published: February-2016
Source: Scleroderma News

Researchers at ChemomAb and Meir Medical Center in Tel Aviv, Israel, and the University of Florence, Italy, recently presented a study investigating the therapeutic effect of the monoclonal antibody CM-101 in animal models of systemic sclerosis (SSc) and idiopathic pulmonary fibrosis (IPF). The data was presented last week in a talk titled “CM-101, a Novel Monoclonal Antibody Blocking CCL24 Ameliorates Experimental Systemic Sclerosis (SSc) and Idiopathic Pulmonary Fibrosis (IPF)” at the 4th Systemic Sclerosis World Congress in Lisbon, Portugal. Systemic sclerosis and IPF are two conditions that involve the development and accumulation of fibrotic tissue and progressive decline of the patient’s health status. 

 

Lung Ailment in Systemic Sclerosis More Aggressive in Men -- But survival the same as in women

Author: Wayne Kuznar
Date Published: February-2016
Source: MedPage Today

Although pulmonary arterial hypertension (PAH) is more common in women with systemic sclerosis (SSc), men had a shorter interlude after an SSc diagnosis to the occurrence of PAH, were younger at the time of PAH diagnosis, and had a shorter PAH disease duration, Canadian researchers found.

 

The crowded crossroad to angiogenesis in systemic sclerosis: where is the key to the problem?

Author: Mirko Manetti, Serena Guiducci and Marco Matucci-Cerinic
Date Published: January-2016
Source: Arthritis Research & Therapy

Dysregulated expression of several proangiogenic and antiangiogenic factors has been implicated in the dysfunction of angiogenesis in systemic sclerosis (SSc). Into this complex scenario comes the study recently published in Arthritis Research & Therapy by Hirigoyen et al. [1], who report new data implicating an inhibitory splice variant of vascular endothelial growth factor (VEGF)-A, namely VEGF165b, in the inhibition of angiogenesis by platelets in SSc. These findings are part of an intriguing chain of data as several studies have shown that VEGF-A, one of the most potent promoters of angiogenesis, is markedly increased in SSc skin and circulation despite clear evidence of an insufficient angiogenic response [2, 3].

 

Treprostinil iontophoresis improves digital blood flow during local cooling in systemic sclerosis

Author: Florence Gaillard-Bigot, Matthieu Roustit, Sophie Blaise, et al
Date Published: January-2016
Source: Microcirculation

Severe Raynaud's syndrome and digital ulcers are the most prevalent manifestations of systemic sclerosis (SSc) peripheral microvascular disease. We tested whether treprostinil iontophoresis on the finger pad of patients with SSc would improve digital blood flow during hand cooling.

 

Genetic factors and systemic sclerosis

Author: Giuseppe Murdacaa, Miriam Contatorea, Rossella Gullib, Paola Mandichb, Francesco Puppoa
Date Published: January-2016
Source: Autoimmunity Reviews

Systemic sclerosis (SSc) is a rare connective tissue disease of unknown etiology characterized by chronic inflammation and fibrosis of the skin, vascular abnormalities, and variable involvement of organs including kidneys, gastrointestinal tract, heart, and lungs. SSc shows a complex etiology in which both environmental and genetic factors seem to influence the onset and outcome of the disease. We provide an extensive overview of the genetic factors and epigenetic modifications and what their knowledge has revealed in terms of etiopathogenesis of SSc.

 

My Hands and Feet Are Always Cold — Should I Worry?

Author: Heart & Vascular Team
Date Published: February-2016
Source: Cleveland Clinic

It’s a familiar scene. You turn up the thermostat; your partner turns it down. Some people struggle with feeling cold all the time — especially when it comes to their hands and feet. If you feel like your extremities are often cold, you may wonder when you should see a doctor. Here’s what you need to know. When blood vessels constrict “Cold hands and feet are a common complaint,” says vascular specialist Natalie Evans, MD. “But generally, when this happens in young healthy people, it isn’t anything to worry about.”

 
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