Skewed X chromosomal inactivation impacts T regulatory cell function in systemic sclerosis.

Author: Broen JC, Wolvers-Tettero IL, Geurts-van Bon L, Vonk MC, Coenen MJ, Lafyatis R, Radstake TR, Langerak AW.
Date Published: August-2010
Source: Annals of Rheumatic Diseases

OBJECTIVES: To investigate the role of X chromosomal inactivation (XCI) in systemic sclerosis (SSc) and its effects on forkhead box P3 (Foxp3) expression in T regulatory cells (Tregs).


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