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Author: Seiichiro Sakao and Koichiro Tatsumia Date Published: August-2010 Source: International Journal of Cardiology
Most patients with severe pulmonary arterial hypertension (PAH) demonstrate persistent structural alterations in small pulmonary arterioles at the time of diagnosis, including marked proliferation of pulmonary artery endothelial cells (ECs), smooth muscle cells (SMCs) and fibroblasts.
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