Localized expression of tenascin in systemic sclerosis–associated pulmonary fibrosis and its regulation by insulin-like growth factor binding protein 3

Author: M. Brissett, K. L. Veraldi, J. M. Pilewski, T. A. Medsger Jr., C. A. Feghali-Bostwick
Date Published: December-2011
Source: Arthritis & Rheumatism

To determine the role of insulin-like growth factor binding protein 3 (IGFBP-3) in mediating the effects of transforming growth factor β (TGFβ) on tenascin-C (TN-C) production and to assess the levels of TN-C in vivo in patients with systemic sclerosis (SSc)–associated pulmonary fibrosis.


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