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Author: Giordano N, Papakostas P, Pecetti G, Nuti R. Date Published: December-2011 Source: Journal of Biologic Regulators
Systemic sclerosis (SSc), also known as scleroderma, is an autoimmune disorder characterized by a progressive fibrosis which involves skin and internal organs, caused by microvascular damage. The earliest clinical sign of the disease is Raynauds Phenomenon, a vasospastic response to cold or stress stimuli, followed by the skin and organ involvement over time.
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