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Author: Happonen KE, Saxne T, Geborek P, et al
Date Published: January-2012 Source: Arthritis Research & Therapy
Cartilage oligomeric matrix protein (COMP) is found at elevated concentrations in sera of patients with joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). We recently showed that COMP activates complement via the alternative pathway and that COMP-C3b complexes are present in sera of RA patients, but not healthy controls.
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