Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-alpha treatment

Author: Happonen KE, Saxne T, Geborek P, et al
Date Published: January-2012
Source: Arthritis Research & Therapy

Cartilage oligomeric matrix protein (COMP) is found at elevated concentrations in sera of patients with joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). We recently showed that COMP activates complement via the alternative pathway and that COMP-C3b complexes are present in sera of RA patients, but not healthy controls.


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