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Author: Haines P, Hant FN, Lafyatis R, Trojanowska M, Bujor AM.
Date Published: January-2012 Source: Journal of Cellular and Molecular Medicine
Previous studies have shown that the TGFβ/Alk1/Smad1 signaling pathway is constitutively activated in a subset of systemic sclerosis (SSc) fibroblasts and this pathway is a critical regulator of CCN2 gene expression. Caveolin-1 (cav-1), an integral membrane protein and the main component of caveolae, has also been implicated in SSc pathogenesis.
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