An Immunochip based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3

Author: Jane Zochling, Felicity Newell, Jac C Charlesworth, et al
Date Published: October-2014
Source: Arthritis Research & Therapy

Introduction: The aim of the study was to interrogate the genetic architecture and autoimmune pleiotropy of scleroderma susceptibility in the Australian population. Methods: We genotyped individuals from a well-characterized cohort of Australian scleroderma patients with the Immunochip, a custom array enriched for single nucleotide polymorphisms (SNPs) at immune loci. Controls were taken from the 1958 British Birth Cohort.