Vascular Biomarkers and Correlation with Peripheral Vasculopathy in Systemic Sclerosis.

Author: Chora I, Guiducci S, Manetti M, et al
Date Published: December-2014
Source: Autoimmunity Reviews

Vascular disease is a hallmark of systemic sclerosis (SSc). It is present in every patient, being responsible both for the earliest clinical manifestations and the major life-threatening complications of the disease, and thus determining important morbidity and mortality. In SSc, progressive vascular injury leads to vascular tone dysfunction and reduced capillary blood flow, with consequent tissue ischemia and chronic hypoxia.