Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures

Author: J. Taroni, V. Martyanov, C. Huang, J. Mahoney, et al
Date Published: July-2015
Source: Arthritis Research & Therapy

Esophageal involvement in patients with systemic sclerosis (SSc) is common, but tissue-specific pathological mechanisms are poorly understood. There are no animal scleroderma esophagus models and esophageal smooth muscle cells dedifferentiate in culture prohibiting in vitro studies. Esophageal fibrosis is thought to disrupt smooth muscle function and lead to esophageal dilatation, but autopsy studies demonstrate esophageal smooth muscle atrophy and the absence of fibrosis in the majority of SSc cases. Herein, we perform a detailed characterization of SSc esophageal histopathology and molecular signatures at the level of gene expression.