Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway

Author: Elena López-Isac, Diana Campillo-Davo, Lara Bossini-Castillo, et al
Date Published: September-2015
Source: Annals of the Rheumatic Diseases

TYK2 is a common genetic risk factor for several autoimmune diseases. This gene encodes a protein kinase involved in interleukin 12 (IL-12) pathway, which is a well-known player in the pathogenesis of systemic sclerosis (SSc). Therefore, we aimed to assess the possible role of this locus in SSc.