Pilot Study to Determine Whether Transient Receptor Potential Melastatin Type 8 (TRPM8) Antibodies Are Detected in Scleroderma

Author: Ami A. Shah, MD, MHS, Janelle Montagne, MS, Sun-Young Oh, PhD, Fredrick M. Wigley, MD, and Livia Casciola-Rosen, PhD
Date Published: January-2016
Source: Clinical & Experimental Rheumatology

A key mediator in cold-sensation is the protein transient receptor potential melastatin 8 (TRPM8), which is expressed on sensory nerves and cutaneous blood vessels. These receptors are activated by cold temperatures and play a key role in body thermoregulation. Cold sensitivity and Raynaud's phenomenon are frequent clinical features in scleroderma, and are thought to be secondary to a local defect in cutaneous thermoregulation. We investigated whether autoantibodies targeting TRPM8 were present in the sera of patients with scleroderma as evidence for a possible mechanism for an acquired immune mediated defect in thermoregulation.