The anti-fibrotic effect of α2AP neutralization in systemic sclerosis dermal fibroblasts and mouse models of systemic sclerosis

Author: Yosuke Kanno, En Shu, Hiroyuki Kanoh, Mariko Seishima
Date Published: December-2015
Source: Science Direct

Systemic sclerosis (SSc) is a connective tissue disease of autoimmune origin characterized by the fibrosis of skin and visceral organs, and peripheral circulatory disturbance. We recently demonstrated that α2-antiplasmin (α2AP), which is the physiological inhibitor of plasmin, is associated with the development of fibrosis. The aim of this study was to clarify the role of α2AP in the pathogenesis of SSc. The administration of α2AP in mice induced pro-fibrotic changes, such as increased dermal thickness, collagen production, and myofibroblast differentiation.