Recent developments in the classification, evaluation, pathophysiology, and management of scleroderma renal crisis

Author: Cybele Ghossein, John Varga, Andrew Z. Fenves
Date Published: December-2015
Source: Current Rheumatology Reports

Scleroderma renal crisis (SRC) is an uncommon complication of systemic sclerosis. Despite the advent of angiotensin-converting inhibitor therapy, SRC remains a life-threatening complication. Recent studies have contributed to a better understanding of SRC, but much remains unknown regarding its pathophysiology, risk factors, and optimal management. Genetic studies provide evidence that immune dysregulation might be a contributing factor, providing hope that further research in this direction might illuminate pathogenesis and provide novel predictors for this complication.