CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis

Author: Florence Roan, Thomas A. Stoklasek, Elizabeth Whalen, Jerry A. Molitor, Jeffrey A. Bluestone, Jane H. Buckner and Steven F. Ziegler
Date Published: January-2016
Source: The Journal of Immunology

Innate lymphoid cells (ILC) are a heterogeneous group of cellular subsets that produce large amounts of T cell–associated cytokines in response to innate stimulation in the absence of Ag. In this study, we define distinct patterns of surface marker and cytokine expression among the ILC subsets that may further delineate their migration and function. Most notably, we found that the subset previously defined as group 1 ILC (ILC1) contains CD4+ CD8−, CD4− CD8+, and CD4− CD8− populations.