Scleroderma
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      • Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort
      • A Role for Lysophosphatidic Acid and Sphingosine 1-Phosphate in the Pathogenesis of Systemic Sclerosis
      • Identification of Myocardial Damage in Systemic Sclerosis: A Nuclear Cardiology Approach
      • Exercise pulmonary hypertension associated with systemic sclerosis: Four distinct entities.
      • Generation of Transgene-Free Lung Disease-Specific Human iPS Cells Using a Single Excisable Lentiviral Stem Cell Cassette.
      • Comparative Proteomic Analysis of Serum from Patients with Systemic Sclerosis and Sclerodermatous GVHD. Evidence of Defective Function of Factor H
      • Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation
      • Acute Kidney Injury In Patients With Systemic Sclerosis Participating In Hematopoietic Cell Transplantation Trials In The United States
      • Skewed X chromosomal inactivation impacts T regulatory cell function in systemic sclerosis.
      • Vascular remodeling in pulmonary arterial hypertension: Multiple cancer-like pathways and possible treatment modalities
      • Recent advances in pulmonary fibrosis: implications for scleroderma.
      • The Role of Progenitor Cells in Lung Disease Prognosis
      • Registry Evaluation of Digital Ulcers in Systemic Sclerosis
      • Distinct evolution of TLR-mediated dendritic cell cytokine secretion in patients with limited and diffuse cutaneous systemic sclerosis.
      • Cellular and molecular aspects of vascular dysfunction in systemic sclerosis
      • Imatinib Promising for Refractory Pulmonary Artery Hypertension
      • Cardiac complications of systemic sclerosis: recent progress in diagnosis.
      • Predicting Survival in Pulmonary Arterial Hypertension. Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)
      • Study Suggests Link Between Scleroderma, Cancer in Certain Patients
      • Gene expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by Iloprost
      • The Vascular Microenvironment and Systemic Sclerosis
      • Rare Gene Variants Associated With Rheumatoid Arthritis, Type 1 Diabetes
      • Validation of the 6 min walk test according to the OMERACT filter: a systematic literature review by the EPOSS-OMERACT group.
      • Type I interferon system activation and association with disease manifestations in systemic sclerosis.
      • Heritability of vasculopathy, autoimmune disease, and fibrosis in systemic sclerosis: a population-based study.
      • Scleroderma Renal Crisis: A Pathology Perspective
      • Arresto: Blocking Fibroblasts
      • Targeting ADAM17-notch signaling abrogates the development of systemic sclerosis in a murine model.
      • Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database
      • Actelion Introduces First Pulmonary Arterial Hypertension (PAH) Multimedia Mobile Application for Healthcare Professionals
      • Scleroderma Care and Research - June 2010
      • The Symptom Burden Index: Development and Initial Findings from Use with Patients with Systemic Sclerosis
      • The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model
      • Systemic sclerosis-associated interstitial lung disease - proposed recommendations for future randomized clinical trials.
      • InterMune Weighs the Odds
      • B-cell Depletion with Rituximab: A Promising Treatment for Diffuse Cutaneous Systemic Sclerosis
      • Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
      • Is dysfunction of caveolin-1 a link between systemic sclerosis and breast cancer, opening a window on both etiologies
      • Granzyme B cleavage of autoantigens in autoimmunity.
      • NIAMS-Funded Scientists Find Potential Target for Fibrosis Treatment
      • Animal models of systemic sclerosis: Prospects and limitations
      • Creating a Pathway in IPF
      • Actelion Hasn’t Seen Top of PAH
      • Lymphatic and blood vessels in scleroderma skin, a morphometric analysis.
      • Antagonistic Effect of the Matricellular Signaling Protein CCN3 on TGF-β- and Wnt-Mediated Fibrillinogenesis in Systemic Sclerosis and Marfan Syndrome
      • Bioactive lipid LPA mediates fibrogenesis in bleomycin mouse model of scleroderma
      • Endothelin-1 and Systemic Sclerosis
      • Pathogenesis of pulmonary fibrosis in systemic sclerosis: lessons from interstitial lung disease.
      • Systemic sclerosis and lupus: Points in an interferon-mediated continuum
      • The Current State of Biomarkers in Systemic Sclerosis
      • Prognosis and treatment of interstitial lung disease in systemic sclerosis (scleroderma)
      • Type I interferons: crucial participants in disease amplification in autoimmunity
      • IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus.
      • Th1 transcription factor T-bet regulates the expression of Tim-3.
      • Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts.
      • Lymphatic and blood vessels in scleroderma skin, a morphometric analysis.
      • Observational study of treatment outcome in early diffuse cutaneous systemic sclerosis.
      • Echocardiography as an outcome measure in scleroderma-related pulmonary arterial hypertension: a systematic literature analysis by the EPOSS group.
      • Medical Mystery Pieced Together
      • Arginetix: Another NO to PAH
      • Expression of the dermatomyositis autoantigen Mi-2 in regenerating muscle.
      • H. Dietz, MD - AAAS Lecture 2009
      • Rapamycin versus methotrexate in early diffuse systemic sclerosis: results from a randomized, single-blind pilot study.
      • D. Kastner, MD Lecture - Fevers, Genes, and Histories: Adventures in the Genomics of Inflammation
      • Rituximab: a potential therapeutic advance in scleroderma What is the evidence?
      • Scleroderma Care and Research - 2009
      • Independent association of anti-beta(2)-glycoprotein I antibodies with macrovascular disease and mortality in scleroderma patients.
      • Botox therapy for ischemic digits
      • Autoantigens in systemic autoimmunity: critical partner in pathogenesis.
      • Clinical profile of anti-PL-12 autoantibody. Cohort study and review of the literature.
      • Bayer Schering Pharma presents positive results of phase II study with Riociguat
      • Is pulmonary arterial hypertension really a late complication of systemic sclerosis?
      • Transforming growth factor β as a therapeutic
      • H. Dietz, MD Lecture - Marfan syndrome and related disorders : from molecules to medicines
      • Recent advances in understanding Marfan syndrome: Should we now treat surgical patients with losartan?
      • Angiotensin II Blockade and Aortic-Root Dilation in Marfan's Syndrome
      • Autoantibodies and Microvascular Damage Are Independent Predictive Factors for the Progression of Raynaud’s Phenomenon to Systemic Sclerosis
      • Development of a Preliminary Scleroderma Gastrointestinal Tract 1.0 Quality of Life Instrument
      • Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13
      • Update on Indices of Disease Activity in Systemic Sclerosis
      • Long-term Proton Pump Inhibitor Therapy and Risk of Hip Fracture
      • Scleroderma Care and Research Spring 2006
      • Scleroderma Care and Research Autumn 2005
      • Scleroderma Care and Research Winter 2004/2005
      • Scleroderma Care and Research Spring 2004
      • Assessment of Damage and Activity in Systemic Sclerosis
      • More Research News
    • Scientific Advisory Board
      • Bruce Alberts, PhD (Chair)
      • David Botstein, PhD
      • Shaun R. Coughlin, MD, PhD
      • Dan Kastner, MD, PhD
      • Regis B. Kelly, PhD
      • Henry Metzger, MD
      • Antony Rosen, MD
      • William J. Rutter, PhD
      • Bruce U. Wintroub, MD
      • George Yancopoulos, MD, PhD
      • Closing Text
    • Grant Guidelines and Applications
      • Post-doctoral Fellowship Guidelines
      • Research Application Guidelines
  • About Us
    • History
    • Board of Directors
      • BOD - Luke Evnin
      • BOD - Kristen Baker Bellamy
      • BOD - Dana Delany
      • BOD - Susan Feniger
      • BOD - Jeff Mace
      • BOD - Bob Saget
      • BOD - Deann Wright
      • BOD - Caryn Zucker
    • Scientific Advisory Board
      • Bruce Alberts, PhD (Chair)
      • David Botstein, PhD
      • Shaun R. Coughlin, MD, PhD
      • Dan Kastner, MD, PhD
      • Regis B. Kelly, PhD
      • Henry Metzger, MD
      • Antony Rosen, MD
      • William J. Rutter, PhD
      • Bruce U. Wintroub, MD
      • George Yancopoulos, MD, PhD
      • Closing Text
    • 2009 Annual Report
      • Annual Report - 2009
      • Annual Report - 2008
    • SRF in the News
      • NHGRI selects new scientific director for intramural research
      • Susan Feniger Plays for SRF on Top Chef Masters - Her Finale Episode
      • Cool Comedy-Hot Cuisine Los Angeles "On The Red Carpet"
      • Susan Feniger's "Touchdown" on Top Chef Masters
      • Andy Richter Takes Round One of the Jeopardy! Celebrity Invitational
      • New round of 'Celebrity Jeopardy' begins
      • Cool Comedy - Hot Cuisine scleroderma benefit
      • At Fundraiser, Housewives Creator Dishes on Finale
      • Robin Williams talks seriously about scleroderma
  • Get Involved
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    • Cool Comedy – Hot Cuisine
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  • For Patients
    • News for Patients
      • Actelion Pharmaceuticals Announces FDA Approval of Brand Name for Commercially Available VELETRI® (epoprostenol for injection) for Pulmonary Arterial Hypertension
      • Ask an Expert About Scleroderma
      • The Unfolding Mystery of Scleroderma
      • Patient Voices: Scleroderma
      • Alternative Therapies for Raynaud’s
      • FDA Approves Remodulin for Pulmonary Hypertension
      • ATS: Patients with PAH Maintain Long-Term Gains
      • Does Exercise Make Raynaud’s Worse?
      • How Serious Is Raynaud’s Phenomenon?
      • Treatment of Pulmonary Hypertension
      • Patient information: Raynaud phenomenon
      • Pathogenesis of the Raynaud phenomenon
      • Nonpharmacologic therapy for the Raynaud phenomenon
      • Ask the Expert: Raynaud’s Phenomenon
      • Experience With Rituximab in Scleroderma: Results From a 1-Year, Proof-of-Principle Study
      • Replacing an Immune System Gone Haywire
      • 2010 FESCA Video Lecture - Renal complications of systemic sclerosis
      • 2010 FESCA Video Lecture - Cardiovascular Issues in Scleroderma
      • 2010 FESCA Video Lecture - Raynaud's Phenomenon
      • 2010 FESCA Video Lecture - Immune Suppression in Sytemic Sclerosis: Past, Present and Future
      • 2010 FESCA Video Lecture - Update on Musculoskeletal Involvement in Systemic Sclerosis
      • 2010 FESCA Video Lecture - Scleroderma Lung Disease: What the patient should know
      • 2010 FESCA Video Lecture - The gastro-intestinal tract in systemic sclerosis
      • 2010 FESCA Video Lecture - Coping with a Chronic Disease
      • 2010 FESCA Video Lecture - Living with Scleroderma
      • Immune compounds start cycle of destruction
      • Prognosis and treatment of interstitial lung disease in systemic sclerosis (scleroderma)
      • Cold feet? It could be Raynaud’s disease
      • Medical Mystery Pieced Together
      • Imatinib Ineffective for Idiopathic Pulmonary Fibrosis
      • Sjogren's Syndrome Symptoms
      • Researchers Revisit Pulmonary Arterial Hypertension Survival
      • NeoPharm seeks US FDA nod for IL13-PE38QQR to treat Idiopathic Pulmonary Fibrosis
      • FDA grants priority review of InterMune IPF treatment
      • Bladder Discomfort
      • Breathlessness Eased in Patients with Rare, Often Fatal Disease
      • D. Kastner, MD 2009 Lecture - Fevers, Genes, and Histories: Adventures in the Genomics of Inflammation
      • Preliminary Results Show Beneficial Effects of Imatinib in Scleroderma
      • Botox Therapy for Ischemic Digits
      • Bayer Schering Pharma presents positive results of phase II study with Riociguat
      • H. Dietz, MD 2009 AAAS Lecture - Marfan syndrome and related disorders : from molecules to medicines
      • More Patient News
    • What is scleroderma
    • Frequently Asked Questions
    • Risk Factors
    • Tips for Living
    • Clinical Trials
    • Current Treatments
      • Treatment News
      • Archived Treatment News
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  • Downloads
    • Annual Report - 2009
    • Sharing the Spotlight: Celebrity Heroes
    • Moving Forward
    • Insights Newsletter
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The Scleroderma Research Foundation is a 501(c)3 nonprofit organization whose mission is to fund and facilitate the most promising medical research aimed at improved therapies and, ultimately, a cure for scleroderma. Information provided by the SRF should not be considered medical advice, nor is it intended to replace consultation with a qualified physician. The SRF does not evaluate, endorse or recommend any particular medications, products, equipment or treatments. Scleroderma varies substantially from one patient to another, and treatment must be tailored by a physician for each individual case.